The Panadea CCHFV IgG ELISA Kit (Research Use Only) allows the qualitative detection of human serum/plasma IgG antibodies directed against the Crimean-Congo-Hemorrhagic Fever Virus (CCHFV) nucleocapsid protein (NP) in 96-well (12x8) format. The test is based on a patented immune complex capture principle.
- Emmerich P et. al. Comparison of diagnostic performances of ten different immunoassays detecting anti-CCHFV IgM and IgG antibodies from acute to subsided phases of Crimean-Congo hemorrhagic fever. PLoS Negl Trop Dis. 2021 Mar 15;15(3)
- Lombe BP et. al. Purification of Crimean-Congo hemorrhagic fever virus nucleoprotein and its utility for serological diagnosis. SciRep. 2021 Jan 27;11(1):2324
- Rahden P et. al. Elevated Human Crimean-Congo Hemorrhagic Fever Virus Seroprevalence in Khashm el Girba, Eastern Sudan. Am J Trop Med Hyg. 2019Jun;100(6):1549-1551
- Emmerich P et. al. Sensitive and specific detection of Crimean-Congo Hemorrhagic Fever Virus (CCHFV)-Specific IgM and IgG antibodies in human sera using recombinant CCHFV nucleoprotein as antigen in μ-capture and IgG immune complex (IC) ELISA tests. PLoSNegl Trop Dis. 2018 Mar 26;12(3)
Surveillance of Crimean-Congo Hemorrhagic Fever Virus prevalence through screening of population samples for antibodies against the virus has importance not only for populations where the disease is known to circulate, but also for public health system preparedness on a world-wide level. As CCHFV can spread from person to person via contact of blood and other bodily fluids, the detection of the CCHF virus in a population is important for the prevention of outbreaks.
IgG antibodies persist in the blood of infected individuals long after the person has recovered from the viral infection. Surveillance studies employing IgG detection are critical for detecting CCHFV in human and ruminant populations without the requirement for the screened individuals to have clinically presented with suspicious symptoms and sampled during the transient period when they contain live virus. This makes IgG detection a valuable tool for observing the prevalence of a virus in a population, especially in Low- and Middle-Income Countries (LMIC), where infections with CCHFV are less likely to be correctly identified at the primary healthcare level.
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