A digital rendering of the Panadea kit box, which is a rectangular box with dark navy blue sides and a white top, which is speckled with a wavy pattern of light blue dots. The Panadea logo, a stylised dark blue P with bubble elements on the top left corner and a filled light blue circle inside the round head of the P stands next to the capitalised, light blue word "PANADEA", under which the smaller font lower case word "diagnostics" in dark navy blue is placed, which ends in a dark navy blue line that extends to the end of the above "PANADEA" text. The sides of the box are adorned with a centralised, white version of the 'bubble element P icon'. The box stands centralised in the image frame on a white background.
Kit description:

The Panadea CCHFV IgG ELISA Kit (Research Use Only) allows the qualitative detection of human serum/plasma IgG antibodies directed against the Crimean-Congo-Hemorrhagic Fever Virus (CCHFV) nucleocapsid protein (NP) in 96-well (12x8) format. The test is based on a patented immune complex capture principle.

Determination of the presence/absence of IgG antibodies directed against CCHFV NP in human serum/plasma.
Test principle:
IgG immune complex ELISA utilizing patented CD32 capture technology.
A tick of the Hyalomma genus, the carrier vector for the Crimean-Congo Hemorrhagic Fever virus, is shown photographed on a red soil background, amidst scattered, sun-bleached twigs. The tick has a dark, near-black body in the shape of a sunflower seed and orange legs that are banded with many dark and light sections.
The disease:
Crimean Congo Hemorrhagic Fever Virus (CCHFV) is the ... and causes ... cases of Crimean-Congo Hemorrhagic Fever per year worldwide. The virus is spread by bites of the ... species ticks (shown) and can spread from human to human through contact with blood and other body fluids.
Read more:

Quick facts

For whom is CCHFV surveillance important?

Surveillance of Crimean-Congo Hemorrhagic Fever Virus prevalence through screening of population samples for antibodies against the virus has importance not only for populations where the disease is known to circulate, but also for public health system preparedness on a world-wide level. As CCHFV can spread from person to person via contact of blood and other bodily fluids, the detection of the CCHF virus in a population is important for the prevention of outbreaks.

Why should IgG antibody detection be used to monitor CCHFV prevalence?

IgG antibodies persist in the blood of infected individuals long after the person has recovered from the viral infection. Surveillance studies employing IgG detection are critical for detecting CCHFV in human and ruminant populations without the requirement for the screened individuals to have clinically presented with suspicious symptoms and sampled during the transient period when they contain live virus. This makes IgG detection a valuable tool for observing the prevalence of a virus in a population, especially in Low- and Middle-Income Countries (LMIC), where infections with CCHFV are less likely to be correctly identified at the primary healthcare level.

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